The Asymmetric Total Synthesis of (+)- and (-)-Trypargine via Noyori Asymmetric Transfer Hydrogenation
نویسندگان
چکیده
Uma síntese total e eficiente da (+) e (-)-tripargina, alcalóide b-carbolínico isolado da pele da rã africana K. Senegalensis, foi realizada em 6 etapas e 38% de rendimento global, a partir da triptamina, tendo como base a construção do sistema b-carbolínico via reação de BischlerNapieralski e a redução enantiosseletiva do intermediário diidro-b-carbolínico via reação de transferência de hidrogênio assimétrica usando o protocolo de Noyori.
منابع مشابه
Asymmetric hydrogenation via architectural and functional molecular engineering*
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